Schizophrenia and the influenza epidemics of 1957 in Japan
Identifieur interne : 000159 ( 1957/Analysis ); précédent : 000158; suivant : 000160Schizophrenia and the influenza epidemics of 1957 in Japan
Auteurs : Yuji Izumoto ; Shimpei Inoue ; Nobufumi Yasuda [États-Unis]Source :
- Biological Psychiatry [ 0006-3223 ] ; 1999.
English descriptors
- KwdEn :
- Teeft :
- Adult schizophrenia, Biol, Biol psychiatry, Birth cohort, Birth cohorts, Cohort, Cohort studies, Comparison period, Confidence interval, December, Epidemic, February, Female births, Female subjects, Fetal, Fetal life, Fifth month, Gestation, Index period, Influenza, Influenza epidemic, Influenza epidemics, Influenza virus, January, Kendell, Kochi, Kochi prefecture, Male subjects, Mcgrath, Mednick, Peak month, Peak months, Prefecture, Prenatal, Prenatal exposure, Present study, Previous studies, Psychiatric institutions, Psychiatry, Relative risk, Schizophrenia, Schizophrenic births, Second trimester, Sham, Takei, Trimester.
Abstract
Abstract: Background: We tested the hypothesis that the exposure to an influenza epidemic during the second trimester of gestation is associated with an increased risk of later development of schizophrenia.Methods: There were three influenza epidemics (A/B mixed type, the first A2 type and the second A2 type) in 1957 in Kochi, Japan. We compared the risk of developing schizophrenia in birth cohorts exposed to these three influenza epidemics during gestation with that in birth cohorts not exposed. To identify subjects who had developed schizophrenia, we surveyed patients with schizophrenia who received medical care at all psychiatric institutions in Kochi prefecture.Results: There is a pattern that schizophrenic births increase twice or more among female subjects who were exposed to each of three influenza epidemics in the fifth month of gestation. The increase in the female births exposed to the second A2 epidemic was significant (relative risk 2.86, 95% confidence interval 1.37–5.26). This pattern across the three epidemics was not observed in male subjects.Conclusions: Prenatal exposure to an influenza epidemic during the second trimester increased the risk of later development of schizophrenia in female births.
Url:
DOI: 10.1016/S0006-3223(98)00359-X
Affiliations:
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We compared the risk of developing schizophrenia in birth cohorts exposed to these three influenza epidemics during gestation with that in birth cohorts not exposed. To identify subjects who had developed schizophrenia, we surveyed patients with schizophrenia who received medical care at all psychiatric institutions in Kochi prefecture.Results: There is a pattern that schizophrenic births increase twice or more among female subjects who were exposed to each of three influenza epidemics in the fifth month of gestation. The increase in the female births exposed to the second A2 epidemic was significant (relative risk 2.86, 95% confidence interval 1.37–5.26). This pattern across the three epidemics was not observed in male subjects.Conclusions: Prenatal exposure to an influenza epidemic during the second trimester increased the risk of later development of schizophrenia in female births.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><noCountry><name sortKey="Inoue, Shimpei" sort="Inoue, Shimpei" uniqKey="Inoue S" first="Shimpei" last="Inoue">Shimpei Inoue</name><name sortKey="Izumoto, Yuji" sort="Izumoto, Yuji" uniqKey="Izumoto Y" first="Yuji" last="Izumoto">Yuji Izumoto</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Yasuda, Nobufumi" sort="Yasuda, Nobufumi" uniqKey="Yasuda N" first="Nobufumi" last="Yasuda">Nobufumi Yasuda</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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